Publications

​Journal Articles

Cell migration in schizophrenia: Patient-derived cells do not regulate motility in response to extracellular matrix.

Jing Yang Tee, Ratneswary Sutharsan, Yongjun Fan, Alan Mackay-Sim.. Molecular and Cellular Neuroscience. 2017. 80: 111-122. doi: 10.1016/j.mcn.2017.03.005

 

Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia.

GautamWali1*, Ratneswary Sutharsan*, Youngjun Fan1, Romal Stewart, JohanaTello, Carolyn M Sue, Denis I. Crane1 & Alan Mackay-Sim. Sci Rep. 2016. 27;6:27004. doi: 10.1038/srep27004. (* co-first author)

 

Schizophrenia patient-derived olfactory neurosphere-derived cells do not respond to extracellular reelin.

Jing Yang Tee, Ratneswary Sutharsan, Youngjun Fan & Alan Mackay-Sim. NPJ Schizophr. 2016. 17;2:16027. doi: 10.1038/npjschz.2016.27

 

Rapid growth in early childhood associated with young adult overweight and obesity - evidence from a community based cohort study. 2015. Ratneswary Sutharsan; Michael J O’Callaghan; Gail Williams; Jake M Najman; Abdulla  A Mamun; J Health Popul Nutr. 2015 Aug 8;33:13. doi: 10.1186/s41043-015-0012-2.

 

Caesarean delivery and the risk of offspring overweight and obesity over the life course: A systematic review and bias-adjusted meta-analysis. 2015. Sutharsan, Ratneswary; Mannan, Munim; Doi, Sohail; Mamun, Abdullah. Clinical Obesity. 5 (6), 293-301

 

Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia. Fan Y, Wali G, Sutharsan R, Bellette B, Crane DI, Sue CM, Mackay-Sim A. 2014. Biol Open. 2014 May 23;3(6):494-502. doi: 10.1242/bio.20147641.

 

Cesarean Delivery and the Long-Term Risk of Offspring Obesity.

Mamun, A. A., Sutharsan, R., O'Callaghan, M., Williams, G., Najman, J., McIntyre, H. D.,  Callaway, L. Obstet Gynecol. 2013 Dec;122(6):1176-83. doi: 10.1097/AOG.0000000000000016

 

A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Stewart R, Kozlov S, Matigian N, Wali G, Gatei M, Sutharsan R, Bellette B, Wraith-Kijas A, Cochrane J, Coulthard M, Perry C, Sinclair K, Mackay-Sim A, Lavin MF. Hum Mol Genet. 2013 Jun 15;22(12):2495-509. doi: 10.1093/hmg/ddt101

 

A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations. Greger Abrahamsen, Yongjun Fan, Nicholas Matigian, Gautam Wali, Bernadette Bellette, Ratneswary Sutharsan, Jyothy Raju, Stephen A Wood, David Veivers, Carolyn M Sue, and Alan Mackay-Sim. 2012. Dis Model Mech. 2013 Mar;6(2):489-502. doi: 10.1242/dmm.010884

 

NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease.

Cook AL, Vitale AM, Ravishankar S, Matigian N, Sutherland GT, Shan J, Sutharsan R, Perry C, Silburn PA, Mellick GD, Whitelaw ML, Wells CA, Mackay-Sim A, Wood SA. PLoS One. 2011;6(7):e21907. doi: 10.1371/journal.pone.0021907

 

Disease-specific, neurosphere-derived cells as models for brain disorders.

Matigian N, Abrahamsen G, Sutharsan R, Cook AL, Vitale AM, Nouwens A, Bellette B, An J, Anderson M, Beckhouse AG, Bennebroek M, Cecil R, Chalk AM, Cochrane J, Fan Y, Féron F, McCurdy R, McGrath JJ, Murrell W, Perry C, Raju J, Ravishankar S, Silburn PA, Sutherland GT, Mahler S, Mellick GD, Wood SA, Sue CM, Wells CA, Mackay-Sim A. Dis Model Mech. 2010 Nov-Dec;3(11-12):785-98. doi: 10.1242/dmm.005447.

 

Selected changes in spinal cord morphology after T4 transection and olfactory ensheathing cell transplantation. 2010. Kalincik T, Jozefcikova K, Sutharsan R, Mackay-Sim A, Carrive P, Waite PME. Auton Neurosci. 2010. 158(1-2):31-8. doi: 10.1016/j.autneu.2010.05.011.

 

Effects of human OEC-derived cell transplants in rodent spinal cord contusion injury. 2010. Catherine Anne Gorrie, Ian Hayward, Nicholas Cameron, Gajan Kailainathan, Neilan Nandapalan, Ratneswary Sutharsan, Jennifer Wang, Alan Mackay-Sim and Phil M.E. Waite. Brain Res. 2010 Jun 14;1337:8-20. doi: 10.1016/j.brainres.2010.04.019. 

 

Olfactory ensheathing cells reduce duration of autonomic dysreflexia in rats with high spinal cord injury. 2010. Kalincik T, Choi EA, Feron F, Bianco J, Sutharsan, R , Hayward I, Mackay-Sim A, Carrive P, Waite PME. Auton Neurosci. 2010 Apr 19;154(1-2):20-9. doi: 10.1016/j.autneu.2009.10.001.

 

A novel cell transplantation protocol and its application to an ALS mouse model. 2008. Morita, E., Watanabe, Y., Ishimoto, M., Nakano, T., Kitayama, M., Yasui, K., Fukada, Y., Doi, K., Karunaratne, A., Murrell, W.G., Sutharsan, R., Mackay-Sim, A., Hata, Y., Nakashima, K.  Exp Neurol. 2008 Oct;213(2):431-8. doi: 10.1016/j.expneurol.2008.07.011.

 

Gene inactivation confirms the identity of enzymes involved in nematode phosphorylcholine-N-glycan synthesis. 2008. Houston, K.M., Sutharsan, R., Steiger, C.N., Schachter, H., Harnett, W Molecular and Biochemical Parasitology.  157 (1): 88-91

 

Antibodies to a merozoite surface protein promote multiple invasion of red blood cells by malaria parasites. 1999. Ramasamy, R., Yasawardena, S., Kanagaratnam, R. (Ratneswary), Buratti, E., Baralle, F.E., Ramasamy, M.S. Parasite Immunology.21:397-407

 

Model multiple antigenic and homopolymeric peptides from non-repetitive sequences of malaria merozoite proteins elicit biologically irrelevant antibodies. 1999. Ramasamy, R., Kanagaratnam, R. (Ratneswary)., Chandanie, P.D.F., Kulachelvy, K., Ramasamy, M.S., Dharmasena, P.M. Biochimica et Biophysica Acta. 1453:115-125

 

Mammalian cell expression of malaria merozoite surface proteins and experimental DNA and RNA immunisation. 1999. Ramasamy, R., Yasawardena, S.G., Kanagaratnam, R. (Ratneswary), Buratti, E., Baralle, F.E., Ramasamy, M.S. Biochimica et Biophysica Acta. 1453:1-13

 

Malaria merozoite surface protein anti-sense oligodeoxynucleotides lack anti-sense activity but function as polyanions to inhibit red cell invasion. 1998. Kanagaratnam, R. (Ratneswary), Misiura, K., Rebowski, G., Ramasamy, R. The International Journal of Biochemistry and Cell Biology. 30:979-985